ABSTRACT
Drug abuse is a problem that causes a wide array of social, emotional, and physical problems and involves both patients and the society. Helping the addicted has always been a priority for physicians and especially psychiatrists. The purpose of this prospective study was to compare the effects of methadone and naltrexone in general well-being of patients undergoing these treatments. Forty-six patients who were taking either methadone or naltrexone were selected and evaluated for a period of 5 months using a 28-item questionnaire about their general health. In spite of the fact that patients undergoing methadone treatment had more severe symptoms and prognoses regarding their age, duration of drug abuse, and number of treatment attempts, these patients showed better general health and social functioning comparing to patients undergoing naltrexone treatment during the 6-month period of this study [P<0.000]. Methadone might be regarded as an effective and useful medicine in treatment of addiction
ABSTRACT
To identify the risk factors of anti TB drug induced hepatitis [ATDH] among the atients with tuberculosis. In a retrospective study, medical records of 3960 notified tuberculosis cases over the five year period [2004-2008] in Khuzestan province Health Center, south west of Iran, were reviewed and ATDH data were analyzed. Inclusion criteria were documented TB, diagnosed based on National Tuberculosis Program [NTP]. Data of ATDH and non ATDH were analyzed in SPSS 16 system and by chi square and exact fisher tests. One hundred ninety eight cases including 65[32.8%] female and 133[67.2%] male with mean age of 43.2 year and SD of 9.5 were registered as ATDH during treatment and follow up period. Differences between HIV infection and intravenous drug injection in ATDH cases and non ATDH patients was statistically significant [[p=0.0001, OR: 14.2], [p=0.0001, OR: 7.5] and [p=0.0001, OR: 11.3] respectively]. Among previously established risk factors for ATDH, HCV infection, IVDU and HIV infection had the most importance